DETAILS OF ON GOING PROJECTS
1. "National Retinoblastoma Project" (ICMR)-Guwahati Site,
Centre code 04 since April 2009 to March 2014, just completed
Principal investigator= Dr. (Mrs) Kasturi Bhattacherjee
The overall aims of the research are to start a national
retinoblastoma registry where retinoblastoma cases will be uniformly
recorded form various centers treating retinoblastoma. A retinoblastoma
registry form has been designed to include all aspects of retinoblastoma
like child identification data, residence of family, presenting illness,
the staging using a common staging system , the examination under
anesthesia, family history of cancer and retinoblastoma . The uniform
histopathology of the enucleated eye or post- chemotherapy enucleated
eye will be studied. The management how it was done by the multiple
modalities is also being recorded . Follow up and survival of the
patients is also being recorded.
The importance of research proposal is that RB is a curable disease.
Pediatric cancers are emerging a national priority as they are curable
in nature. The epidemiology of the disease has to be studied and this
will enable us to identify the research areas in Retinoblastoma and
especially plan strategy to decrease the mortality, decrease enucleation
and decrease the incidence of retinoblastoma over a decade .
2. On -going "Ophthalmic Telepathology
Project" between Sankara Nethralaya, Chennai and Sri Sankaradeva
Nethralaya, Guwahati, Assam, INDIA
Principal investigator= Dr. Dipankar Das from Sri Sankaradeva Nethralaya
Telecommunication technologies offer new ways of delivering health
care to individuals in remote communities and usefulness of telemedicine
is increasingly being studies for verity of medical conditions. Telemedicine
technologies are applicable in ophthalmology, because standard ophthalmic
instruments can be modified to capture and store images that can be
digitalized and transmitted for expert evaluation.
Therefore, objectives of telepathlogy are to make service assessable
and affordable by reducing travel cost and time for the patients to
give pathologic at remote places access to specialized opinion from
experts, to minimize the delay in diagnosis and help them share their
experiences and tom help in training and research.
We at Sankara Netralaya, Chennai, India and Sri Sankaradeva Nethralaya,
Guwahati Assam are perusing through a static telepathology project.
The benefit expected by introduction of this telepathology unit are
better medical service, more distributed speclialization, conservation
of time, money and increased knowledge sharing.
3. ICMR sponsored SN-SSN technology transfer
project "To train and develop infrastructure of molecular ophthalmic
pathology and rapid diagnosis of ocular infection in a ophthalmic
institute of Assam"
Principal investigator= Dr. Harsha Bhattacherjee
A. Research Component with training Component
To understand the pathobiology of retinoblastoma in the following
a. To study the expression of multidrug resistant proteins Pgp by
b. To study the expression of human papilloma Virus 16 and 18 genome
in retinoblastoma by nested PCR and insitu hybridization
c. to investigate the cell cycle proteins in retinoblastoma.
B. To train technical personel
In ophthalmic pathology, microbiology techniques and in rapid diagnosis
of ophthalmic infectious agents.
C. To develop infrastructure
For ophthalmic pathology laboratory to enable the personel at institute
to do both routine and molecular ophthalmic pathology and also enable
them to do molecular microbiology for rapid diagnostics in ocular
4. DBT funded project: Proteomics
based identification and validation of urinary biomarkers for the
Age - Related Macular Degeneration
Principal investigator= Dr. Harsha Bhattacharjee
Recent advances in the treatment of coroidal neovascualrization (CMV)
in age related macular degeneration (AMD) have dramatically improved
the outcome in this late stage complications. However, they are still
remains no effective treatment for geographic atrophy and apart from
general lifestyle advice, there are no specific interventions to slow
or reverse progression from early AMD to late stages of the disease.
Guymer et al [Identification of urinary biomarkers for age related
macular degeneration invest Ophthalmol Vis. Sci. 2011 Apr 15] have
identified urinary pro-inflammatory cytokines, transforming growth
factor-ß1, Macrophage Chemo attractant protein-1 and C3 a-desArg,
as potential noninvasive biomarkers for monitoring AMD.
We would like to validate these urinary biomarkers in Indian AMD patients.
The validation of the urinary biomarker would be done at three institute
- at Sri Sankaradeva Nethralaya, Sankara Netralaya, IOB Bangalore.
5. Prevalance and causes
of amblyopia in children aged 6 months to 16 years in kamrup (metro)
district". Recently started under ICMR
Principal investigator= Dr. (Mrs.) Damaris Magdalene
Amblyopia is a scourge in the society, and an important public health
problem because of the irreparable visual loss it causes if the child
is not treated at the proper time. It affects the social, economical,
behavioral, educational, physical and psychological aspects of a community.
The aim of this project is to determine the prevalence, highlight
the magnitude of the disease and find out the causes of amblyopia
in children below 16 years of age. Also to aid the government to implement
health care policy like early vision screening which is currently
hampered by a lack of basic information regarding the true prevalence
of these diseases and the best screening approaches.
6. Srimanta Sankaradeva University of Health Sciences(SSUHS) sponsored
project ' Association between Structural and refractive component
of eye and Diabetic Retinopathy'
Just approved on 21st October 2014
Principal investigator= Dr. Harsha Bhattacharjee
Objective: The objectives of the present study are to find out -
i. Incidence of diabetic retinopathy in the study population.
ii. Refractive status of the eye affected with diabetic retinopathy.
iii. Association between structural and refractive component of eye
and diabetic retinopathy.
Diabetic Retinopathy is an important cause of
blindness. Individuals with higher axial length of the eye (myopia)
are observed to be at low risk of development of Diabetic Retinopathy.
The exact association between myopia and its structural components
is under evaluation. The aim of the research is to find out the incidence
of various refractive status of the eye in patients with diabetic
retinopathy and association between axial length (AL), anterior chamber
depth (ACD) and refractive (Lens biometry and corneal curvature) components
and diabetic retinopathy. Student't' test and multivarient analysis
will be done for testing the statistical significance of various incidence
and associations respectively.
7. Srimanta Sankaradeva University of Health
Sciences(SSUHS) sponsored project 'Correlation of Biochemical Parameters-HBA
Ic Lipid Profile and Apo Lipoprotiens in Adult Diabetic patients with
Just approved on 21st October 2014
Principal investigator= Dr. Krishna Gogoi
Objective: The objectives of the present study are
to find out -
To determine the blood Glucose fasting and post prandial, HBA1c levels,
Cholestrol, triglyceride, HDL-C, LDL-C and apolipoproteins A1 and
apo b and Apo-B to Ap-A1 ratio in adult Diabetic patients with Diabetic
Compare the association of the above parameters with clinical presentation
of DR and evaluate the above parameters as predictive risk factors.
Diabetic retinopathy (DR) is a multi- factorial microvascular
complication occurring in Diabetic patients which may lead to different
degrees of visual impairment and at times to blindness.
Our aim is to conduct a prospective cross sectional
study of the glycemic control (fasting and post prandial blood sugar,
HBA1c), Cholestrol, triglyceride, HDL-C, LDL-C, VLDL and Apolipoproteins
A1 and B in three groups of adult patients - diabetic with DR and
without DR and patients without Diabetes mellitus (DM) or hypertension
attending Sri Sankardeva Nethralaya, Guwahati during the first year.
A thorough history will be taken. Data will be compiled and analysed
in the second year.
This will be the first study of this kind from this
region which will provide a data to work on. Considering the rapid
spread of global epidemic of Diabetes mellitus and incidence of DR
it will help in controlling risk factors identified.